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Latest SIBO Research Summaries
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Real-world Study of Three-gas Breath Testing Nationwide and the Association With Symptoms.
Journal of clinical gastroenterology
This nationwide study of 3,004 people tested three gases in breath tests—hydrogen, methane, and hydrogen sulfide—to see how they relate to digestive symptoms. Hydrogen sulfide levels were strongly linked to diarrhea and more severe symptoms overall, while methane correlated with constipation and hydrogen with diarrhea.
Read Full SummaryGastrointestinal involvement in systemic sclerosis: A spotlight on small bowel involvement, complications and management.
Best practice & research. Clinical rheumatology
This review examines small bowel (intestinal) problems in systemic sclerosis patients, a condition where the immune system attacks connective tissue. The authors summarize current knowledge about how these bowel problems develop, how they're diagnosed, and how they should be treated, with focus on complications like bacterial overgrowth and intestinal pseudo-obstruction (when the intestines stop moving properly without physical blockage).
Read Full SummaryEffectiveness of the low FODMAP diet in patients with irritable bowel syndrome and small intestine bacterial overgrowth syndrome.
Frontiers in nutrition
This study surveyed 98 adults with IBS (irritable bowel syndrome) and/or SIBO/IMO to evaluate how well the low FODMAP diet reduced their digestive symptoms. Over 90% of IBS patients reported symptom improvement, with bloating showing the greatest reduction, though less than half found the diet easy to follow and only 44% completed the full program.
Read Full SummaryMechanisms and pathophysiology leading to development of small intestinal microbial dysbiosis.
The lancet. Gastroenterology & hepatology
This review examines how small intestinal microbial dysbiosis (SIMD)—an overgrowth of bacteria, archaea, or fungi in the small intestine—develops when the body's natural defenses fail. The authors describe the protective mechanisms that normally prevent overgrowth (stomach acid, digestive enzymes, bile, gut movement, and immune function) and identify which medical conditions disrupt these defenses, leading to SIMD.
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